The comments were part of the annual event in Manhattan, a series of discussions with some of the moment’s biggest newsmakers in business and global politics. Earlier, Ken Griffin, the founder and chief executive of Citadel, was the first guest onstage, saying that with the House, Senate and the White House in the hands of Republicans, “we have a chance to govern.”

Serena Williams, the 23-time Grand Slam Champion and managing partner of Serena Ventures, spoke about her tennis career, women’s sports and her venture capital fund. Here’s the rest of this year’s lineup in Eastern time.

1:40 p.m. Jerome Powell, Chair of the Board of Governors of the Federal Reserve System (livestreamed on nytimes.com)

2:10 p.m. Alex Cooper, host of the “Call Her Daddy” podcast and founder of the Unwell Network

2:35 p.m. David Ricks, chair and C.E.O. of Eli Lilly and Company and Fatima Cody Stanford, Obesity Medicine Physician at Massachusetts General Hospital/Harvard Medical School

3:20 p.m. Prince Harry, The Duke of Sussex, co-founder of the Archewell Foundation and chief impact officer of BetterUp

3:50 p.m. Sundar Pichai, C.E.O. of Google

4:50 p.m. Jeff Bezos, the founder and executive chairman of Amazon, the founder of Blue Origin (livestreamed on nytimes.com)

Mr. Griffin said he voted for President-elect Donald J. Trump. He has been one of the top donors to Republican campaigns, including this year, but he didn’t donate to Mr. Trump’s victorious campaign. He had previously derided Mr. Trump as a “three-time loser.” Despite sitting on the sidelines for the Trump campaign, Mr. Griffin said he was happy that Mr. Trump prevailed.

“I will do whatever I can do to help support the president-elect,” he said.

Mr. Griffin downplayed one of the biggest concerns about Trumponomics — that tariffs could dent growth and accelerate inflation. He said it remained unclear whether Mr. Trump’s threats to slap tariffs on Mexico, Canada and China would materialize, adding that the talk of tariffs imposed by the United States was “small ball compared to the role that the world is looking to us for.” He said he didn’t see tariffs as the most important business issue.

Mr. Griffin, who had publicly pushed for the Apollo Global Management chief executive Marc Rowan for Treasury Secretary, said he didn’t have any personal experience with Mr. Trump’s ultimate choice, Scott Bessent. Mr. Griffin was wary of some of Mr. Bessent’s ideas for potentially limiting the independence of the Federal Reserve. The Fed’s autonomy, he said, was “incredibly important to the preservation and strength of our economy.” He also said it was “extraordinarily important to the sanctity of the dollar.”

While criticizing the Biden administration’s “reckless fiscal spending,” Mr. Griffin was skeptical that Elon Musk, who Mr. Trump said would run what he has called the Department of Government Efficiency, could succeed in slashing government spending.

“It’ll be very hard to squeeze numbers in the trillions of dollars out of the baseline budget,” Mr. Griffin said. “In particular, because we’ve increased interest expense in such a profound way” over the last eight years. Cuts, Mr. Griffin added, will be “politically very unpopular.”

Mr. Griffin, who has long been a critic of the cryptocurrency industry, said he was still not convinced that it solved problems in the economy, even as a massive rally in Bitcoin has pushed its value above $96,000 on Wednesday. But he has softened his stance against the crypto sector, and acknowledged that it “may have a future” as people seek to “get away from the yoke of government.”

Sam Altman is a co-founder and the chief executive of OpenAI, the start-up behind ChatGPT and DALL-E. The company set off the artificial-intelligence boom in 2022 and was valued at $157 billion in October.

Jeff Bezos is the founder and executive chairman of Amazon. He also founded Blue Origin, an aerospace company, and is the owner of The Washington Post.

Bill Clinton was the president of the United States from 1993 to 2001. He also wrote the book “Citizen: My Life After the White House.”

Alex Cooper created, produces and hosts the “Call Her Daddy” podcast. Vice President Kamala Harris appeared in an episode during her presidential campaign.

Ken Griffin is the founder and chief executive of Citadel and the founder and nonexecutive chairman of Citadel Securities. He is one of the country’s biggest donors to Republican political candidates.

Sundar Pichai is the chief executive of Google and its parent company, Alphabet. He is also a member of the Alphabet’s board of directors. Google, one of the biggest players vying for dominance in artificial intelligence, has faced multiple antitrust cases in recent years.

Prince Harry, the Duke of Sussex, started the Archewell Foundation with his wife, Meghan, the Duchess of Sussex. He is also the chief impact officer at the coaching app BetterUp.

Jerome H. Powell was sworn in as the chair of the Federal Reserve in 2018. During his tenure, the central bank had raised interest rates to their highest level in decades in an effort to cool off inflation — only to lower them in recent months. Mr. Powell also made headlines last month when he firmly pushed back against the suggestion that President-elect Donald J. Trump could sideline him before his term was scheduled to end in 2026.

David Ricks is the chair and chief executive of Eli Lilly, which along with Novo Nordisk, has dominated the huge market for GLP-1 prescription weight-loss drugs.

Fatima Cody Stanford is an associate professor of medicine and pediatrics who specializes in obesity medicine. She also teaches at the Massachusetts General Hospital and Harvard Medical School.

Serena Williams, considered one of the greatest professional athletes ever, won 23 career Grand Slam tennis tournaments before retiring in 2022. She is the managing partner of Serena Ventures.

Since its inception, DealBook has become an integral part of The Times’s digital and print report with scoops and in-depth features, as well as the annual DealBook Summit, which since 2012 has interviewed scores of newsmakers, from Elon Musk, Jensen Huang of Nvidia, and the former FTX chief executive Sam Bankman-Fried to Vice President Kamala Harris and Prime Minister Benjamin Netanyahu of Israel.

Mr. Sorkin, who began writing for The Times when he was still in high school, has broken major stories including Chase’s acquisition of J.P. Morgan and Hewlett-Packard’s takeover of Compaq. In February, he broke the news that Adam Neuman, the co-founder of WeWork, was trying to buy the company out of bankruptcy.

Mr. Sorkin is the author of the book “Too Big to Fail,” a chronicle of the 2008 global financial crisis. He has won two Gerald Loeb Awards, a marquee prize in business journalism, and helped create the Showtime television series “Billions.” He is also a an anchor on the CNBC financial news program “Squawk Box.”

Mr. Musk accused advertisers that had pulled their money from X, following his endorsement of an antisemitic conspiracy theory, of trying to “blackmail” him. He used an expletive multiple times to emphasize his point. Mr. Musk also shared his concerns about the rapid-fire development of artificial intelligence and OpenAI, the chatbot maker he had co-founded and later left over philosophical differences. That feud has since grown into one of the tech world’s most closely watched lawsuits.

Mr. Musk opened up about his demons, his passions, what drives him and what bugs him. He said he wouldn’t vote to re-elect President Biden, but he also expressed misgivings about Donald J. Trump.

The world knows what happened next: He became Mr. Trump’s biggest supporter, helping and bankrolling him to victory last month in the race for the White House.

Since 2012, the DealBook Summit has brought together the biggest newsmakers in business, policy and culture to speak candidly about the global economy and the forces shaping it. Prominent interviewees have included the Microsoft co-founder Bill Gates, the former Secretary of State Hillary Rodham Clinton and the entrepreneur and social media influencer Kim Kardashian.

The one-day conference has also featured interviews with Sam Bankman-Fried, the fallen crypto executive convicted of masterminding one of the biggest business frauds of recent times, as well as Treasury Secretary Janet Yellen and BlackRock’s chief executive, Larry Fink.