The Archdiocese of Los Angeles, the nation’s largest, has agreed to pay $880 million to 1,353 people who say they were sexually abused as children by Catholic clergy. The settlement, which experts said was the highest single payout by a diocese, brings Los Angeles’s cumulative total in sex abuse lawsuits to more than $1.5 billion.

The settlement was announced on Wednesday in a joint statement by lawyers for the plaintiffs and the archdiocese.

“I am sorry for every one of these incidents, from the bottom of my heart,” Archbishop José H. Gomez said in a statement. “My hope is that this settlement will provide some measure of healing for what these men and women have suffered.”

The settlement tops the previous high for a diocese, from 2007, when L.A. agreed to pay $660 million in lawsuits brought by 508 people, said Terence McKiernan, the president of BishopAccountability.org, a watchdog group that has tracked clergy abuse reports for decades.

“There are a lot more dominoes in California to come down,” he said, referring to other dioceses that have not reached settlements or protected themselves by filing for bankruptcy.

The agreement represents the near conclusion to decades of litigation against the archdiocese, with only a few suits remaining. Over the years, the archdiocese has sold off real estate, liquidated investments and taken out loans to cover the staggering costs of litigation.

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