Vice President Kamala Harris has agreed to an interview with Fox News, the network said on Monday.

The interview, with Fox News’s chief political anchor, Bret Baier, will take place near Philadelphia on Wednesday, shortly before it airs at 6 p.m. Eastern on Mr. Baier’s program, “Special Report.” Ms. Harris is expected to sit for 25 to 30 minutes of questions, the network said.

This is Ms. Harris’s first formal interview with Fox News, whose day-to-day programming is heavy on conservative punditry that often explicitly supports her Republican opponent, former President Donald J. Trump.

It could also represent an opportunity for the Democratic nominee three weeks ahead of Election Day.

Ms. Harris will have a chance to deliver her message to a viewership that may be skeptical of her candidacy. Her willingness to appear on Fox News may aid the perception that she is open to facing tough questions. And she can reach a swath of independent voters, more of whom watch Fox News than CNN or MSNBC, according to research by Nielsen.

Senior Democratic officials have long shown hostility toward Fox News, going so far as to formally bar the network from hosting a primary debate in 2020. Hillary Clinton, in 2016, was the last Democratic presidential nominee to sit for a Fox News interview. President Biden has not appeared on the network since taking office, though he has jousted at news conferences with its senior White House correspondent, Peter Doocy.

But a thaw has occurred.

Ms. Harris’s running mate, Gov. Tim Walz of Minnesota, was interviewed on “Fox News Sunday” the past two weekends. (Mr. Walz’s aides reached out to Fox to schedule his second appearance.) In recent months, the network has also welcomed a string of Harris supporters, including Gov. Gavin Newsom of California, Gov. Josh Shapiro of Pennsylvania, and Transportation Secretary Pete Buttigieg, who is now such a regular that he cheekily told Democratic convention-goers, “You might recognize me from Fox News.”

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