For the first time, Vice President Kamala Harris dismissed criticism from some Republicans that she does not have biological children, saying in a podcast interview on Sunday that much of the commentary was “meanspirited” and misunderstood women who either can’t have children or simply did not want to.

In an appearance on the podcast “Call Her Daddy,” which is popular with Gen Z and millennial women, Ms. Harris discussed reproductive rights and economic issues. She addressed comments from Sarah Huckabee Sanders, the governor of Arkansas, who recently suggested that having biological children helped with her humility — a virtue she implied Ms. Harris lacked.

“I don’t think she understands that there are a whole lot of women out here who, one, are not aspiring to be humble,” Ms. Harris told the host, Alex Cooper. “Two, a whole lot of women out here who have a lot of love in their life, family in their life and children in their life. And I think it’s really important for women to lift each other up.”

When the conversation turned to attacks by Republicans against “childless cat ladies,” Ms. Harris called the criticism, popularized by past comments by Senator JD Vance of Ohio, former President Donald J. Trump’s running mate, “mean and meanspirited.” Ms. Harris referred to her stepchildren, Cole and Ella Emhoff, as her children.

“I love those kids to death,” Ms. Harris said. “And family comes in many forms. I think that increasingly, you know, all of us understand that this is not the 1950s anymore.”

The “Call Her Daddy” interview was part of several appearances that Ms. Harris will make this week with news outlets and niche podcasts or radio shows. Several of the platforms are considered to be friendly to her, or at least far less probing than a traditional news interview would be.

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